A technological platform to overcome tumor resistance to anticancer therapies
Online streaming via MS Teams
29 JUNE 2021
10:00 – 12:45
2nd p-care workshop on precision cancer medicine
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By leveraging Italian and Austrian excellence in genetics, clinics and biotechnology, the p-care cross-border collaboration takes aim at cancer drug resistance and develops innovative strategies for re-sensitizing tumors to therapies and spurring the immune system to fight cancer.

Our goals

Tavola disegno 1 copy 2TO STUDY the mechanisms of antineoplastic drug resistanceTO FOSTER synergies and cross-border networks of excellence TO TEST the efficacy of existing drugs to overcome tumor resistance TO BOOST research capacity and infrastructures by sharing experiences and technologies TO EXPLORE personalized medicine approaches in order to recapitulate patient’s tumor microenvironment and immune response in lab

Workplan

1 Obtaining biological samples from patients

Chips of patients' tumors and their surrounding tissues will be recovered during surgery or biopsy and sent to p-care labs, along with patients’ blood samples.

2 Developing avatars

Collected samples will be subject to different procedures in order to develop complex, 3D cell systems (organoids and spheroids) containing different types of cells. Developed systems will imitate the tumor-of-origin and its tissue microenvironment.

3 Studying drug resistance mechanisms

Developed systems will be treated with different drugs used in anti-cancer therapy in order to analyse their response and the contribution of the microenvironment to it. Resistant cells will be identified and characterized by means of various analyses. Data obtained from tumor organoids and spheroids will be used to identify key determinants of drug resistance.

4 Experimenting novel therapeutic strategies

Collections of drugs will be tested on different cell systems in combination with conventional therapies to evaluate drug synergism and effective overcoming of treatment resistance.

5 Generating resources

Biological material, generated tumor- and tissue-like systems, and data will be collected and stored for reuse in research. They will expand the cross-border biobank initiated with a previous interreg project, PreCanMed.

6 Transferring and exchanging knowledge

Training activities and material will be developed in order to make p-care technologies and methods available to biologists, clinical oncologists, bioinformaticians and other professionals in the field of cancer biology and medicine.

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Highlights
21/12/2020
PUBLICATION

Insights on patient-specific breast tumors

p-care partner Giannino Del Sal and his team at the University of Trieste, Italy, have published a research article today in the international journal Cancers (Basel).

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05/12/2020
EVENT

The 1st p-care Workshop on Precision Cancer Medicine successfully concluded

138 people in all were connected and followed the event from the crossborder regions involved in the project.

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04/12/2020
EVENT

1st p-care Workshop

The first p-care workshop on precision cancer medicine will be held online today, starting at 11:00.

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p-care

Research lead

UNITS
Università degli studi di Trieste
Italy

partners

ADSI
Austrian Drug Screening Institute
Austria
MUI
Medizinische Universität Innsbruck
Austria
SABES
Azienda Sanitaria dell'Alto Adige - Comprensorio sanitario di Bolzano
Italy

P-Care

is a project funded by the European Union, European Regional Development Fund and Interreg V-A Italia-Austria 2014-2020

sschoeftner@units.it

Università degli Studi di Trieste - DSV Via Weiss 2 - Pal. Q 34128 Trieste

Ph +39 040 558 8743

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